Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity
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چکیده
منابع مشابه
A novel proteoliposomal vaccine elicits potent antitumor immunity in mice.
Therapeutic vaccination against idiotype is a promising strategy for immunotherapy of B-cell malignancies. Its feasibility, however, is limited by the requirement for a patient-specific product. Here we describe a novel vaccine formulation prepared by simply extracting cell-membrane proteins from lymphoma cells and incorporating them together with IL-2 into proteoliposomes. The vaccine was prod...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2019
ISSN: 1529-2908,1529-2916
DOI: 10.1038/s41590-019-0500-4